Tissue Repair

KPV

KVP

Cut from the same parent hormone as PT-141, but works on a completely different pathway — no arousal effects, no pigmentation changes, just anti-inflammatory signalling. Most of the research sits in gut inflammation (colitis models in mice) and skin irritation, with some antimicrobial activity against bacteria including MRSA reported too. Like BPC-157 and TB-500, there's no completed human trial behind any of it — the strongest single dataset dates back to 2008, and it's animal data.

Anti-inflammatory tripeptide derived from alpha-MSH that blocks NF-κB signalling without activating .

How well studied

Tier Guide: A = Well studied, B = Some good studies, C = Early evidence & D = Barely studied

CHow well studiedEarly evidence

Mostly animal studies or very small early trials in humans. We don't really know yet how it behaves in people.

Heightened caution: this compound carries unresolved regulatory, safety or supply-chain concerns in the UK. Nothing here is a recommendation to use it.

How it works

Gets pulled into cells through a gut-lining transporter and jams a switch called NF-κB that turns on inflammation — without touching the arousal or pigmentation pathway its parent hormone uses.

Enters cells via the PepT1 transporter and inhibits NF-κB, blocking transcription of pro-inflammatory cytokines including TNF-α, IL-1β and IL-6, independent of activity.

Reported benefits

Blocks inflammatory signalling in gut and skin tissue in animal studies
Some antimicrobial activity reported against bacteria including MRSA

Who it's typically used for

Gut inflammation, skin irritation — animal-model evidence only, no confirmed human effect

Timeline to results

Unknown — no controlled human timeline exists; anecdotal reports vary by route (oral, topical, injection)

Dosage

No established human dose

No established human dose — zero completed dose-response trials, same evidence gap as BPC-157 and TB-500.

Side effects

No human trial safety data existsunknown
General injection or oral-route reactions reported anecdotallyunverified

Getting it in the UK

Getting it in the UKPrescribable, but not approved for this

Still legal for a doctor to prescribe, but it hasn't been officially approved for this specific use. Uncommon, and comes down to a specialist's own judgement.

MHRA: the UK government body that checks a medicine is safe and actually works before doctors are allowed to prescribe it.

Content freshness

Last reviewed: 15 Aug 2026
Regulatory status last checked: 15 Aug 2026